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Industry News                                                                                                                                                                                                    Industry News










          FRAUNHOFER IPMS

          DEVELOPS HIGH-DENSITY

          CHIPLET AT WAFER LEVEL                                                                                                 MED-TECH UPDATE













          Researchers at the Fraunhofer Institute for Photonic   Quasi-monolithic integration is envisaged to be ideal           New implantable Device to improve Outcomes for         expected, reliably producing singlet oxygen on demand
          Microsystems have developed a technique that          for applications such as highly integrated system-on-            Bladder Cancer                                         and confirming the potential for the system to be used
          allows different chip components to be to be fused    chip solutions for artificial intelligence systems and                                                                  as an implantable device to support photodynamic
                                                                                                                                 Engineers and scientists at the University of Glasgow
          almost seamlessly into a single unit. By precisely    high-bandwidth smart transceivers.                                                                                      therapy.
                                                                                                                                 have developed an implantable device which is hoped
          embedding small chiplets into specially structured
                                                                Dr. Lukas Lorenz, Group Leader at Fraunhofer IPMS,               to improve outcomes for bladder cancer patients by     Dr. Rolan Mansour of the James Watt School of
          silicon pockets the team successfully combined
                                                                states:                                                          maximising the effectiveness of light-sensitive drugs.  Engineering at the University of Glasgow states:
          the advantages of a compact single chip with the
          flexibility of modular systems for the first time.       “ The basis of QMI is silicon wafers with structural          Wirelessly powered micro-LEDs are used to enhance the    “ Today bladder cancers cause 16 deaths a day in the
          This achievement demonstrates the feasibility of         recesses, or pockets. For the first time, dummy               delivery of light through tissue-mimicking models in the   UK alone according to figures from Cancer Research
          quasi-monolithic integration and bridges the gap         chiplets have been inserted into these pocket                 lab.                                                     UK. However, bladder cancer, like many others, is
          between traditional chip packaging and cutting-          wafers and the surface has been levelled with a                                                                        potentially curable if it is diagnosed and treated
                                                                                                                                 The principle deployed is that of photodynamic therapy,
          edge semiconductor manufacturing. The aim is to          passivation layer in preparation for subsequent                                                                        early, before metastatic spread or invasion into other
          integrate various chip components, such as control       back-end-of-line wiring. This creates a nearly                which uses light-sensitive drugs called photosensitisers   organs. Given that photodynamic therapy has the
          electronics, sensors and micromechanical systems         monolithic system architecture that combines the              to selectively destroy cancer cells. It is commonly used   potential for less side effects and could improve
          (MEMS) at the wafer level, whilst at the same time       highest integration density with modular scalability.         in the treatment of skin cancer, but its effectiveness is   cancer treatment outcomes, our work is focused on
                                                                                                                                 currently constrained by the physical properties of body
          retaining the benefits of a compact single chip.                                                                                                                                improving the effectiveness of delivering light where
                                                                   Although the current demonstrator is based on
                                                                                                                                 tissues. The tissues tend to absorb light, making it more   it’s most needed, to the photosensitisers which tackle
          Advantages are realised over conventional packaging      dummy structures, the process chain can be                    challenging for doctors to access some types of tumours   and kill cancer cells. “
          processes due to the way chiplets are arranged on        transferred to real-world customer applications.              which grow deeper in the body, as, for example, in the
          an active or passive wafer substrate with a shared       This enables a scalable integration architecture for          bladder.
          interconnect stack. Since the interconnects are          future heterogeneous system solutions. “
                                                                                                                                 The new device is designed to be flexible and small
          formed in the front-end-of-line process, much higher   Reference: ‘The Future of Chip Integration: Fraunhofer IPMS develops
                                                                                                                                 enough to be implanted next to tumours so that light can
          connection densities can be achieved than with        High-density Chiplet Systems at the Wafer Level’, Commercial Micro
                                                                Manufacturing International, 19th. May                           reach treatment sites more directly, minimising the need
          traditional methods.
                                                                                                                                 for invasive procedures, whilst by drawing power from a
                                                                                                                                 wireless source the need for external power is removed.
                                                                                                                                 The device is disc-shaped and 40mm wide. It was
                                                                                                                                 fabricated at the James Watt Nanofabrication Centre
            Visit our website!                                                                                                   and uses four micro-LEDs on a flexible substrate of
                                                                                                                                 Paryline C, a biocompatible polymer used for medical
                                                                                                                                 implants. Using power drawn wirelessly via resonant
                                                                                                                                 inductive coupling, the LEDs can deliver optical outputs in
            Why not head down to our website and                                                                                 excess of five megawatts.
            read more news in our blog section?                                                                                  In laboratory tests using materials designed to closely   Professor David Flynn, leader of the EPSRC PATIENT
                                                                                                                                 mimic human tissues, it was shown that light could     project at the James Watt School of Engineering, adds:
                                                                                                                                 be sent with minimal loss through slices of synthetic
            Updated daily with hand-picked articles                                                                              tissues up to 50mm thick. A photosensitiser solution     “ These are very encouraging results, which
                                                                                                                                                                                          demonstrate how flexible bioelectronics, wireless
            from around the web...                                                                                               was also used to test how the system could be used
                                                                                                                                 to generate singlet oxygen, which is a highly-reactive,   power delivery and photonics can be combined to
                                                                                                                                                                                          create advanced, minimally invasive treatments,
                                                                                                                                 cancer-destroying molecule that is produced by the
            institutionofelectronics.ac.uk                                                                                       interaction between photosensitisers and light. Findings   which could improve the clinical outcomes of
                                                                                                                                                                                          photodynamic therapies.
                                                                                                                                 showed that the solution reacted to light from the LEDs as


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